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1.

Platelet-derived growth factor signaling in pericytes promotes hypothalamic inflammation and obesity.

Okekawa, Akira; Wada, Tsutomu; Onogi, Yasuhiro; Takeda, Yuki; Miyazawa, Yuichiro; Sasahara, Masakiyo; Tsuneki, Hiroshi; Sasaoka, Toshiyasu.

Mol Med; 30(1): 21, 2024 Feb 05.

Artículo en Inglés | MEDLINE | ID: mdl-38317079

2.

Oestrogen receptor α in T cells controls the T cell immune profile and glucose metabolism in mouse models of gestational diabetes mellitus.

Tanaka, Tomoko; Wada, Tsutomu; Uno, Kimie; Ogihara, Saki; Ie, Hiromi; Okekawa, Akira; Ishikawa, Akari; Ito, Tetsuo; Miyazawa, Yuichiro; Sameshima, Azusa; Onogi, Yasuhiro; Tsuneki, Hiroshi; Sasahara, Masakiyo; Nakashima, Akitoshi; Saito, Shigeru; Sasaoka, Toshiyasu.

Diabetologia; 64(7): 1660-1673, 2021 07.

Artículo en Inglés | MEDLINE | ID: mdl-33796910

3.

Total Synthesis of Decahydroquinoline Poison Frog Alkaloids ent-cis-195A and cis-211A.

Okada, Takuya; Wu, Naizhen; Takashima, Katsuki; Ishimura, Jungoh; Morita, Hiroyuki; Ito, Takuya; Kodama, Takeshi; Yamasaki, Yuhei; Akanuma, Shin-Ichi; Kubo, Yoshiyuki; Hosoya, Ken-Ichi; Tsuneki, Hiroshi; Wada, Tsutomu; Sasaoka, Toshiyasu; Shimizu, Takahiro; Sakai, Hideki; Dwoskin, Linda P; Hussaini, Syed R; Saporito, Ralph A; Toyooka, Naoki.

Molecules; 26(24)2021 Dec 12.

Artículo en Inglés | MEDLINE | ID: mdl-34946611

4.

Stromal cell-derived factor 1 (SDF1) attenuates platelet-derived growth factor-B (PDGF-B)-induced vascular remodeling for adipose tissue expansion in obesity.

Watanabe, Eri; Wada, Tsutomu; Okekawa, Akira; Kitamura, Fuka; Komatsu, Go; Onogi, Yasuhiro; Yamamoto, Seiji; Sasahara, Masakiyo; Kitada, Munehiro; Koya, Daisuke; Tsuneki, Hiroshi; Sasaoka, Toshiyasu.

Angiogenesis; 23(4): 667-684, 2020 11.

Artículo en Inglés | MEDLINE | ID: mdl-32699964

5.

N-acetylaspartate availability is essential for juvenile survival on fat-free diet and determines metabolic health.

Hofer, Dina C; Zirkovits, Gabriel; Pelzmann, Helmut J; Huber, Katharina; Pessentheiner, Ariane R; Xia, Wenmin; Uno, Kyosuke; Miyazaki, Toh; Kon, Kanta; Tsuneki, Hiroshi; Pendl, Tobias; Zoughbi, Wael Al; Madreiter-Sokolowski, Corina T; Trausinger, Gert; Abdellatif, Mahmoud; Schoiswohl, Gabriele; Schreiber, Renate; Eisenberg, Tobias; Magnes, Christoph; Sedej, Simon; Eckhardt, Matthias; Sasahara, Masakiyo; Sasaoka, Toshiyasu; Nitta, Atsumi; Hoefler, Gerald; Graier, Wolfgang F; Kratky, Dagmar; Auwerx, Johan; Bogner-Strauss, Juliane G.

FASEB J; 33(12): 13808-13824, 2019 12.

Artículo en Inglés | MEDLINE | ID: mdl-31638418

6.

[Insulin resistance and cognitive function].

Sasaoka, Toshiyasu; Wada, Tsutomu; Tsuneki, Hiroshi.

Nihon Rinsho; 72(4): 633-40, 2014 Apr.

Artículo en Japonés | MEDLINE | ID: mdl-24796090

7.

C-terminal peptide of preproorexin enhances brain-derived neurotrophic factor expression in rat cerebrocortical cells and recognition memory in mice.

Tsuneki, Hiroshi; Honda, Kosuke; Sekine, Yurika; Yahata, Koji; Yasue, Moeka; Fujishima, Masashi; Takeda, Ryuta; Wada, Tsutomu; Sasaoka, Toshiyasu.

Eur J Pharmacol; 964: 176306, 2024 Feb 05.

Artículo en Inglés | MEDLINE | ID: mdl-38145647

8.

Eplerenone ameliorates the phenotypes of metabolic syndrome with NASH in liver-specific SREBP-1c Tg mice fed high-fat and high-fructose diet.

Wada, Tsutomu; Miyashita, Yusuke; Sasaki, Motohiro; Aruga, Yusuke; Nakamura, Yuto; Ishii, Yoko; Sasahara, Masakiyo; Kanasaki, Keizo; Kitada, Munehiro; Koya, Daisuke; Shimano, Hitoshi; Tsuneki, Hiroshi; Sasaoka, Toshiyasu.

Am J Physiol Endocrinol Metab; 305(11): E1415-25, 2013 Dec 01.

Artículo en Inglés | MEDLINE | ID: mdl-24129399

9.

A transdermal treatment with MC903 ameliorates diet-induced obesity by reducing visceral fat and increasing myofiber thickness and energy consumption in mice.

Wada, Tsutomu; Miyazawa, Yuichiro; Ikurumi, Misa; Fuse, Kento; Okekawa, Akira; Onogi, Yasuhiro; Saito, Shigeru; Tsuneki, Hiroshi; Sasaoka, Toshiyasu.

Nutr Metab (Lond); 20(1): 10, 2023 Feb 11.

Artículo en Inglés | MEDLINE | ID: mdl-36774476

10.

Resting phase-administration of lemborexant ameliorates sleep and glucose tolerance in type 2 diabetic mice.

Tsuneki, Hiroshi; Sugiyama, Masanori; Sato, Kiyofumi; Ito, Hisakatsu; Nagai, Sanaka; Kon, Kanta; Wada, Tsutomu; Kobayashi, Nao; Okada, Takuya; Toyooka, Naoki; Kawasaki, Masashi; Ito, Toshihiro; Otsubo, Ryota; Okuzaki, Daisuke; Yasui, Teruhito; Sasaoka, Toshiyasu.

Eur J Pharmacol; 961: 176190, 2023 Dec 15.

Artículo en Inglés | MEDLINE | ID: mdl-37952563

11.

Hachimijiogan, a traditional herbal medicine, modulates adipose cell function and ameliorates diet-induced obesity and insulin resistance in mice.

Kagawa, Syota; Tanabe, Katsuya; Hiromura, Makoto; Ogawa, Kakuyou; Koga, Takayuki; Maeda, Takahiro; Amo-Shiinoki, Kikuko; Ochi, Hiroyuki; Ichiki, Yui; Fukuyama, Shogo; Suzuki, Saori; Suizu, Natsuki; Ohmine, Takaaki; Hamachi, Sakurako; Tsuneki, Hiroshi; Okuya, Shigeru; Sasaoka, Toshiyasu; Tanizawa, Yukio; Nagashima, Fumihiro.

Front Pharmacol; 14: 1167934, 2023.

Artículo en Inglés | MEDLINE | ID: mdl-37251332

12.

Central versus peripheral impact of estradiol on the impaired glucose metabolism in ovariectomized mice on a high-fat diet.

Yonezawa, Rika; Wada, Tsutomu; Matsumoto, Natsumi; Morita, Mayuko; Sawakawa, Kanae; Ishii, Yoko; Sasahara, Masakiyo; Tsuneki, Hiroshi; Saito, Shigeru; Sasaoka, Toshiyasu.

Am J Physiol Endocrinol Metab; 303(4): E445-56, 2012 Aug 15.

Artículo en Inglés | MEDLINE | ID: mdl-22550066

13.

Role of orexin in the central regulation of glucose and energy homeostasis.

Tsuneki, Hiroshi; Wada, Tsutomu; Sasaoka, Toshiyasu.

Endocr J; 59(5): 365-74, 2012.

Artículo en Inglés | MEDLINE | ID: mdl-22293586

14.

Multitasking bamboo leaf-derived compounds in prevention of infectious, inflammatory, atherosclerotic, metabolic, and neuropsychiatric diseases.

Kimura, Ikuko; Kagawa, Syota; Tsuneki, Hiroshi; Tanaka, Kaori; Nagashima, Fumihiro.

Pharmacol Ther; 235: 108159, 2022 07.

Artículo en Inglés | MEDLINE | ID: mdl-35183589

15.

Suvorexant and mirtazapine improve chronic pain-related changes in parameters of sleep and voluntary physical performance in mice with sciatic nerve ligation.

Ito, Hisakatsu; Tsuneki, Hiroshi; Sasaoka, Toshiyasu; Toyooka, Naoki; Matsuo, Mitsuhiro; Yamazaki, Mitsuaki.

PLoS One; 17(2): e0264386, 2022.

Artículo en Inglés | MEDLINE | ID: mdl-35213655

16.

Ebselen enhances insulin sensitivity and decreases oxidative stress by inhibiting SHIP2 and protects from inflammation in diabetic mice.

Polianskyte-Prause, Zydrune; Tolvanen, Tuomas A; Lindfors, Sonja; Kon, Kanta; Hautala, Laura C; Wang, Hong; Wada, Tsutomu; Tsuneki, Hiroshi; Sasaoka, Toshiyasu; Lehtonen, Sanna.

Int J Biol Sci; 18(5): 1852-1864, 2022.

Artículo en Inglés | MEDLINE | ID: mdl-35342343

17.

Hypothalamic orexin prevents non-alcoholic steatohepatitis and hepatocellular carcinoma in obesity.

Tsuneki, Hiroshi; Maeda, Takahiro; Takata, Shinjiro; Sugiyama, Masanori; Otsuka, Koyuki; Ishizuka, Hinako; Onogi, Yasuhiro; Tokai, Emi; Koshida, Chiaki; Kon, Kanta; Takasaki, Ichiro; Hamashima, Takeru; Sasahara, Masakiyo; Rudich, Assaf; Koya, Daisuke; Sakurai, Takeshi; Yanagisawa, Masashi; Yamanaka, Akihiro; Wada, Tsutomu; Sasaoka, Toshiyasu.

Cell Rep; 41(3): 111497, 2022 10 18.

Artículo en Inglés | MEDLINE | ID: mdl-36261021

18.

Food odor perception promotes systemic lipid utilization.

Tsuneki, Hiroshi; Sugiyama, Masanori; Ito, Toshihiro; Sato, Kiyofumi; Matsuda, Hiroki; Onishi, Kengo; Yubune, Koharu; Matsuoka, Yukina; Nagai, Sanaka; Yamagishi, Towa; Maeda, Takahiro; Honda, Kosuke; Okekawa, Akira; Watanabe, Shiro; Yaku, Keisuke; Okuzaki, Daisuke; Otsubo, Ryota; Nomoto, Masanori; Inokuchi, Kaoru; Nakagawa, Takashi; Wada, Tsutomu; Yasui, Teruhito; Sasaoka, Toshiyasu.

Nat Metab; 4(11): 1514-1531, 2022 11.

Artículo en Inglés | MEDLINE | ID: mdl-36376564

19.

Both type I and II IFN induce insulin resistance by inducing different isoforms of SOCS expression in 3T3-L1 adipocytes.

Wada, Tsutomu; Hoshino, Masashi; Kimura, Yukari; Ojima, Minoru; Nakano, Tetsuro; Koya, Daisuke; Tsuneki, Hiroshi; Sasaoka, Toshiyasu.

Am J Physiol Endocrinol Metab; 300(6): E1112-23, 2011 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-21386060

20.

Human adipose tissue is a putative direct target of daytime orexin with favorable metabolic effects: A cross-sectional study.

Goldstein, Nir; Tsuneki, Hiroshi; Bhandarkar, Nikhil; Aimaretti, Eleonora; Haim, Yulia; Kon, Kanta; Sato, Kiyofumi; Wada, Tsutomu; Liberty, Idit F; Kirshtein, Boris; Dukhno, Oleg; Maixner, Nitzan; Gepner, Yftach; Sasaoka, Toshiyasu; Rudich, Assaf.

Obesity (Silver Spring); 29(11): 1857-1867, 2021 11.

Artículo en Inglés | MEDLINE | ID: mdl-34472713

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